Advances in Stem Cell Aging
Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for exemple, the regeneration of skeletal muscle. In addition to its function in [...]
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Auteur : Karl LENHARD RUDOLPH
Editeur : Karger
Date parution : 10/2012Bilingue : Français | Anglais
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Adult stem cells are present in most postnatal tissues of mammals.
Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for exemple, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells tan represent the cell type of origin of varions types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalien tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells.
This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Krôner-Fresenius Symposium on Advances in Stem Cell Aging in 2011.
It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physiciens and scientists specializing in geriatric medicine, internal medicine, and surgery.
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ContentsVII Preface Pahernik, S. (Heidelberg)
Introduction Rudolph, KL (Ulm)
Chapter 1
2 Speakers at the Symposium Morita, M. (Ulm)
Chapter 2
18 Aging of the Niche and the Microenviro,nment and Its Role in Stem CeU Aging Geiger, H. (Ulm)
Chapter3
27 Hematopoietic Stem CeU Aging and Cancer Chen, Y; Ju, Z. (Hangzhou)
Chapter4
36 DNA Damage, Checkpoint Responses, and CeU Cycle Control in Aging Stem CeUs ' Kleinhans, K.N.; Burkhalter, MO. (Ulm)
Chapter 5
48 Hematopoietic Stem CeU Aging and Fate Decision Illing, A.; Morita, Y (Ulm)
Chapter6 74 Stem Cell Therapy and Stress Response in Pancreas and Intestine
Sperka, T; Omrani, O. (Ulm)
Chapter 7
87 Niche-Stem Cellinterations and Environmentallnfluences
Tang, O. (Ulm)
Chapter 8
92 Stem Cells and Metabolism
Missios, p.; Guachalla, L. (Ulm)
Chapter9 100 Molecular Mechanisms of Muscle Stem Cell Aging
Baig, A.H.; Tümpel, S. (Ulm)
Chapter 10 112 Neural Stem Cells in·Development and Aging
Schmidt-Straf3burger, U. (Ulm)
121 Author Index
122 Subject Index
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